![]() ![]() ![]() ![]() It is well known that decreased expression of E‐cadherin, a cell adhesion molecule located at the plasma membrane, is important for initiation of the EMT process. Thus, studies that investigate the molecular mechanisms underlying the progression and metastasis of NSCLC would be valuable for development of novel therapeutic options for lung cancer in the clinic.Įpithelial‐mesenchymal transition (EMT) is a phenotypic switching process that induces a loss of epithelial features and a gain of mesenchymal features, including enhanced migration and invasion capacities.ĮMT of tumor cells plays a crucial role in facilitating tumor progression and metastasis. Most cases of lung cancer are non‐small‐cell lung cancer (NSCLC) (approximately 85%), which can be further classified as adenocarcinoma, squamous cell carcinoma, or large cell carcinoma.Īlthough multiple strategies, including surgery, chemotherapy, radiotherapy, and immunotherapy, have been applied in the clinical treatment of NSCLC, the 5‐year overall survival (OS) rate of NSCLC patients at all stages is only 16%. Lung cancer is one of the most common cancers in men and women, and is the leading cause of cancer‐related death (approximately 25% of all cancer deaths) worldwide.
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